Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart.

ABSTRACT: Long QT syndrome (LQTS) can lead to ventricular arrhythmia and sudden cardiac death. The most common congenital cause of LQTS is mutations in the channel subunits generating the cardiac potassium current I_Ks. Zebrafish (Danio rerio) have been proposed as a powerful system to model human cardiac diseases due to the similar electrical properties of the zebrafish heart and the human heart. We used high-resolution all-optical electrophysiology on ex vivo zebrafish hearts to assess the effects of I_Ks analogues on the cardiac action potential. We found that chromanol 293B (an I_Ks inhibitor) prolonged the action potential duration (APD) in the presence of E4031 (an I_Kr inhibitor applied to drug-induced LQT2), and to a

SUBMITTER: De la Cruz A 

PROVIDER: S-EPMC10418701 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature