The Sigma Receptors in Alzheimer's Disease: New Potential Targets for Diagnosis and Therapy.

ABSTRACT: Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ₁) receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), and the sigma-2 (σ₂) receptor, located in the ER-resident membrane. Increasing evidence indicates the involvement of both σ₁ and σ₂ receptors in the pathogenesis of Alzheimer's disease (AD), and thus these receptors represent two potentially effective biomarkers for emerging AD therapies. The availability of optimal radioligands for positron emission tomography (PET) neuroimaging of the σ₁ and σ₂ receptors in humans will provide tools to monitor AD progression and treatment outcomes. In this review, we first summarize the significance of bo

SUBMITTER: Wang T 

PROVIDER: S-EPMC10418732 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature