New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.

ABSTRACT: Preeclampsia (PE) is a pregnancy-specific disorder affecting 4-10% of all expectant women. It greatly increases the risk of maternal and foetal death. Although the main symptoms generally appear after week 20 of gestation, scientific studies indicate that the mechanism underpinning PE is initiated at the beginning of gestation. It is known that the pathomechanism of preeclampsia is strongly related to inflammation and oxidative stress, which influence placentation and provoke endothelial dysfunction in the mother. However, as of yet, no "key players" regulating all these processes have been discovered. This might be why current therapeutic strategies intended for prevention or treatment are not fully effective, and the only effective method to stop the disease is the premature induction of

SUBMITTER: Sakowicz A 

PROVIDER: S-EPMC10418829 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature