Structural Insights into the Giardia lamblia Target of Rapamycin Homolog: A Bioinformatics Approach.

ABSTRACT: TOR proteins, also known as targets of rapamycin, are serine/threonine kinases involved in various signaling pathways that regulate cell growth. The protozoan parasite Giardia lamblia is the causative agent of giardiasis, a neglected infectious disease in humans. In this study, we used a bioinformatics approach to examine the structural features of GTOR, a G. lamblia TOR-like protein, and predict functional associations. Our findings confirmed that it shares significant similarities with functional TOR kinases, including a binding domain for the FKBP-rapamycin complex and a kinase domain resembling that of phosphatidylinositol 3-kinase-related kinases. In addition, it can form multiprotein complexes such as TORC1 and TORC2. These results provide valuable insights into the str

SUBMITTER: Munoz-Munoz PLA 

PROVIDER: S-EPMC10418948 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature