Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β.

ABSTRACT: The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various cellular responses to stress conditions, inflammatory signals, and differentiation factors. They are constitutively active in chronic inflammatory diseases and some cancers. The differences between their transient effects in response to signals and the chronic effect in diseases are not known. The family is composed of four isoforms, of which p38α seems to be abnormally activated in diseases. p38α and p38β are almost identical in sequence, structure, and biochemical and pharmacological properties, and the specific unique effects of each of them, if any, have not yet been revealed. This study aimed to reveal the specific effects induced by p38α and p38β, both when transiently activated in response to str

SUBMITTER: Melamed Kadosh D 

PROVIDER: S-EPMC10419006 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature