Resveratrol-Loaded <i>Attalea funifera</i> Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells.

ABSTRACT: This study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 μg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 μg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cyto

SUBMITTER: Dourado D 

PROVIDER: S-EPMC10419039 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature