Emergence delirium and postoperative delirium associated with high plasma NfL and GFAP: an observational study.

ABSTRACT:

Background

Neuroinflammation and neuronal injury have been reported to be associated with the development of postoperative delirium in both preclinical and clinical settings. This study aimed to investigate the potential correlation between biomarkers of neurofilament light chain and glial fibrillary acidic protein and emergence and postoperative delirium in elderly patients undergoing surgery.

Methods

Patients who developed emergence delirium (n = 30) and postoperative delirium (n = 32), along with their matched controls, were enrolled after obtaining ethics approval and written informed consent. Delirium was assessed using the Confusion Assessment Method for the Intensive Care Unit or Confusion Assessment Method scale, and blood samples were collected before

SUBMITTER: Liu X 

PROVIDER: S-EPMC10419211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature