Two pediatric patients with hemiplegic migraine presenting as acute encephalopathy: case reports and a literature review.

ABSTRACT:

Introduction

Hemiplegic migraine (HM) is a rare subtype of migraine. HM in children may be atypical in the initial stage of the disease, which could easily lead to misdiagnosis.

Methods

We report two cases of atypical hemiplegic migraine that onset as an acute encephalopathy. And a comprehensive search was performed using PubMed, Web of Science, and Scopus. We selected only papers that reported complete clinical information about the patients with CACNA1A or ATP1A2 gene mutation.

Results

Patient #1 showed a de novo mutation, c.674C>A (p. Pro225His), in exon 5 of the CACNA1A gene. And patient #2 showed a missense mutation (c.2143G>A, p. Gly715Arg) in exon 16 of the ATP1A2. Together with our two cases, a total of 160 patients (73 CACNA1A and 87 ATP1A2) were collected an

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC10419215 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature