Gene-Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors.

ABSTRACT: Asthma is a complex heterogeneous disease caused by gene-environment interactions. Although numerous genome-wide association studies have been conducted, these interactions have not been systemically investigated. We sought to identify genetic factors associated with the asthma phenotype in 66,857 subjects from the Health Examination Study, Cardiovascular Disease Association Study, and Korea Association Resource Study cohorts. We investigated asthma-associated gene-environment (smoking status) interactions at the level of single nucleotide polymorphisms, genes, and gene sets. We identified two potentially novel (SETDB1 and ZNF8) and five previously reported (DM4C, DOCK8, MMP20, MYL7, and ADCY9) genes associated with increased asthma risk. Nu

SUBMITTER: Cha J 

PROVIDER: S-EPMC10419280 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature