Raman Spectroscopy Profiling of Splenic T-Cells in Sepsis and Endotoxemia in Mice.

ABSTRACT: Sepsis is a life-threatening condition that results from an overwhelming and disproportionate host response to an infection. Currently, the quality and extent of the immune response are evaluated based on clinical symptoms and the concentration of inflammatory biomarkers released or expressed by the immune cells. However, the host response toward sepsis is heterogeneous, and the roles of the individual immune cell types have not been fully conceptualized. During sepsis, the spleen plays a vital role in pathogen clearance, such as bacteria by an antibody response, macrophage bactericidal capacity, and bacterial endotoxin detoxification. This study uses Raman spectroscopy to understand the splenic T-lymphocyte compartment profile changes during bona fide bacterial sepsis versus hyperinflamma

SUBMITTER: Osadare IE 

PROVIDER: S-EPMC10419286 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature