Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease.

ABSTRACT: Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery of the founding member, MAST2, in 1993, three additional family members have been identified in mammals and found to be broadly expressed across various tissues, including the brain, heart, lung, liver, intestine and kidney. The study of MAST kinases is highly relevant for unraveling the molecular basis of a wide range of different human diseases, including breast and liver cancer, myeloma, inflammatory bowel disease, cystic fibrosis and various neuronal disorders. Despite several reports on potential substrates and binding partners of MAST kinases, the molecular mechanisms that would explain their involvement in human di

SUBMITTER: Rumpf M 

PROVIDER: S-EPMC10419289 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature