Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas.

ABSTRACT:

Purpose

Clinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably heterogeneous, yet identification of patients at high risk for treatment failure is challenging. Furthermore, CNSL diagnosis often remains unconfirmed because of contraindications for invasive stereotactic biopsies. Therefore, improved biomarkers are needed to better stratify patients into risk groups, predict treatment response, and noninvasively identify CNSL.

Patients and methods

We explored the value of circulating tumor DNA (ctDNA) for early outcome prediction, measurable residual disease monitoring, and surgery-free CNSL identification by applying ultrasensitive targeted next-generation sequencing to a total of 306 tumor, plasma, and CSF specimens from 136 patients with brain cancers, inclu

SUBMITTER: Mutter JA 

PROVIDER: S-EPMC10419411 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature