Exploring potential network pharmacology-and molecular docking-based mechanism of melittin in treating rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a type of difficult-to-cure arthralgia with a worldwide prevalence. It severely affects people's living standards. For a long time, bee venom has been used to treat RA and has shown good results. Melittin is the main active component of bee venom used for RA treatment, but the molecular mechanism of melittin in RA treatments remains unclear.

Methods

Potential melittin and RA targets were obtained from relevant databases, and common targets of melittin and RA were screened. The STRING database was used to build the PPI network and screen the core targets after visualization. The core targets were enriched by Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway. Finally, the binding of melittin to targe

SUBMITTER: Yang L 

PROVIDER: S-EPMC10419517 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature