Significance of Five-Membered Heterocycles in Human Histone Deacetylase Inhibitors.

ABSTRACT: Five-membered heteroaromatic rings, in particular, have gained prominence in medicinal chemistry as they offer enhanced metabolic stability, solubility and bioavailability, crucial factors in developing effective drugs. The unique physicochemical properties and biological effects of five-membered heterocycles have positioned them as key structural motifs in numerous clinically effective drugs. Hence, the exploration of five-ring heterocycles remains an important research area in medicinal chemistry, with the aim of discovering new therapeutic agents for various diseases. This review addresses the incorporation of heteroatoms such as nitrogen, oxygen and sulfur into the aromatic ring of these heterocyclic compounds, enhancing their polarity and facilitating both aromatic stacking interactio

SUBMITTER: Fruhauf A 

PROVIDER: S-EPMC10419652 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature