Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases.

ABSTRACT: The progressive deterioration of function and structure of brain cells in neurodegenerative diseases is accompanied by mitochondrial dysfunction, affecting cellular metabolism, intracellular signaling, cell differentiation, morphogenesis, and the activation of programmed cell death. However, most of the efforts to develop therapies for Alzheimer's and Parkinson's disease have focused on restoring or maintaining the neurotransmitters in affected neurons, removing abnormal protein aggregates through immunotherapies, or simply treating symptomatology. However, none of these approaches to treating neurodegeneration can stop or reverse the disease other than by helping to maintain mental function and manage behavioral symptoms. Here, we discuss alternative molecular targets for neurodegeneratio

SUBMITTER: Plascencia-Villa G 

PROVIDER: S-EPMC10419704 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature