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Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases.

ABSTRACT: Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.

SUBMITTER: Jiang S

PROVIDER: S-EPMC10419859 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases.

Jiang Shufan S Yang Huili H Li Mingqing M

International journal of molecular sciences 20230807 15

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfuncti ...[more]

PMID: 37569902

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