Intervention Approaches in Studying the Response to Vitamin D₃ Supplementation.

ABSTRACT: Vitamin D intervention studies are designed to evaluate the impact of the micronutrient vitamin D₃ on health and disease. The appropriate design of studies is essential for their quality, successful execution, and interpretation. Randomized controlled trials (RCTs) are considered the "gold standard" for intervention studies. However, the most recent large-scale (up to 25,000 participants), long-term RCTs involving vitamin D₃ did not provide any statistically significant primary results. This may be because they are designed similarly to RCTs of a therapeutic drug but not of a nutritional compound and that only a limited set of parameters per individual were determined. We propose an alternative concept using the segregation of study participants into different groups

SUBMITTER: Gospodarska E 

PROVIDER: S-EPMC10420637 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature