Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain.

ABSTRACT: Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients' quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenance of neuropathy but also in the effectiveness of analgesic drugs. Currently, approximately 50 chemokines are known to act through 20 different seven-transmembrane G-protein-coupled receptors l

SUBMITTER: Pawlik K 

PROVIDER: S-EPMC10421203 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature