Nanoceria as Safe Contrast Agents for X-ray CT Imaging.

ABSTRACT: Cerium oxide nanoparticles (CeO₂NPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce atom's high Z number makes it an ideal candidate for utilisation as an X-ray imaging contrast agent. We herein show how the injection of albumin-stabilised 5 nm CeO₂NPs into mice revealed substantial enhancement in X-ray contrast, reaching up to a tenfold increase at significantly lower concentrations than commercial or other proposed contrast agents. Remarkably, these NPs exhibited prolonged residence time within the target organs. Thus, upon injection into the tail vein, the

SUBMITTER: Garcia A 

PROVIDER: S-EPMC10421217 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature