Vitamin D-An Effective Antioxidant in an Animal Model of Progressive Multiple Sclerosis.

ABSTRACT: Vitamin D (VD) is the most discussed antioxidant supplement for multiple sclerosis (MS) patients and many studies suggest correlations between a low VD serum level and onset and progression of the disease. While many studies in animals as well as clinical studies focused on the role of VD in the relapsing-remitting MS, knowledge is rather sparse for the progressive phase of the disease and the development of cortical pathology. In this study, we used our established rat model of cortical inflammatory demyelination, resembling features seen in late progressive MS, to address the question about whether VD could have positive effects on reducing cortical pathology, oxidative stress, and neurofilament light chain (NfL) serum levels. For this purpose, we used male Dark Agouti (DA) rats, with on

SUBMITTER: Haindl MT 

PROVIDER: S-EPMC10421326 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature