Sulforaphane Reduces the Chronic Inflammatory Immune Response of Human Dendritic Cells.

ABSTRACT:

Background

Sulforaphane (SFN) is an isothiocyanate of vegetable origin with potent antioxidant and immunomodulatory properties. The characterization of its pleiotropic activity in human dendritic cells (DCs) is poorly summarized. The aim of this work was to study the immunomodulatory power of SFN in response to an inflammatory microenvironment on human monocyte-derived DCs (moDCs).

Methods

We studied the immunological response induced by SFN. Apoptosis and autophagy assays were performed using flow cytometry on moDCs and a cancer cell line (THP-1). These included moDC maturation, lymphocyte proliferation and cytokine production under different experimental conditions. We investigated whether these results were associated with an inflammatory microenvironment induced by lipop

SUBMITTER: Fernandez-Prades L 

PROVIDER: S-EPMC10421388 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature