The contribution of late HIV diagnosis on the occurrence of HIV-associated tuberculosis.

ABSTRACT:

Objectives

To describe the timing of tuberculosis (TB) presentation in relation to diagnosis of HIV infection and antiretroviral therapy (ART) initiation and to evaluate whether the established impact from late presentation to care and late initiation of ART on the risk of TB is retained beyond the observation period of clinical trials.

Design

We used marginal structural models to emulate a clinical trial with up to 5 years of follow-up to evaluate the impact of late initiation on TB risk.

Methods

People with HIV (PWH) were enrolled from 2007 to 2016 in observational cohorts from Uganda, Peru, Mexico and Italy. The risk of TB was compared in LP (accessing care with CD4 + cell count ≤350 cells/μl) vs. nonlate presentation using survival curves and a weighted Cox regres

SUBMITTER: Girardi E 

PROVIDER: S-EPMC10421563 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature