The landscape of the immunoglobulin repertoire in endemic pemphigus foliaceus.

ABSTRACT:

Introduction

Primarily driven by autoreactive B cells, pemphigus foliaceus (PF) is an uncommon autoimmune blistering skin disease of sporadic occurrence worldwide. However, PF reaches a prevalence of 3% in the endemic areas of Brazil, the highest ever registered for any autoimmune disease, which indicates environmental factors influencing the immune response in susceptible individuals. We aimed to provide insights into the immune repertoire of patients with PF living in the endemic region of the disease, compared to healthy individuals from the endemic region and a non-endemic area.

Methods

We characterized the B-cell repertoire in i) nontreated patients (n=5); ii) patients under immunosuppressive treatment (n=5); iii) patients in remission without treatment (n=6); and two c

SUBMITTER: Calonga-Solis V 

PROVIDER: S-EPMC10421657 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature