A cost-benefit analysis for use of large SNP panels and high throughput typing for forensic investigative genetic genealogy.

ABSTRACT: Next-generation sequencing (NGS), also known as massively sequencing, enables large dense SNP panel analyses which generate the genetic component of forensic investigative genetic genealogy (FIGG). While the costs of implementing large SNP panel analyses into the laboratory system may seem high and daunting, the benefits of the technology may more than justify the investment. To determine if an infrastructural investment in public laboratories and using large SNP panel analyses would reap substantial benefits to society, a cost-benefit analysis (CBA) was performed. This CBA applied the logic that an increase of DNA profile uploads to a DNA database due to a sheer increase in number of markers and a greater sensitivity of detection afforded with NGS and a higher hit/association rate due to

SUBMITTER: Budowle B 

PROVIDER: S-EPMC10421786 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature