Oculomotor abnormalities indicate early executive dysfunction in prodromal X-linked dystonia-parkinsonism (XDP).

ABSTRACT:

Background

X-Linked dystonia-parkinsonism (XDP) is a movement disorder characterized by the presence of both dystonia and parkinsonism with one or the other more prominent in the initial stages and later on manifesting with more parkinsonian features towards the latter part of the disease. XDP patients show oculomotor abnormalities indicating prefrontal and striatal impairment. This study investigated oculomotor behavior in non-manifesting mutation carriers (NMC). We hypothesized that oculomotor disorders occur before the appearance of dystonic or parkinsonian signs. This could help to functionally identify brain regions already affected in the prodromal stage of the disease.

Methods

Twenty XDP patients, 13 NMC, and 28 healthy controls (HC) performed different oculomotor tas

SUBMITTER: Mertin R 

PROVIDER: S-EPMC10421788 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature