Comparison of genome replication fidelity between SARS-CoV-2 and influenza A virus in cell culture.

ABSTRACT: Since the emergence of COVID-19, several SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) variants have emerged and spread widely. These variants are produced through replication errors of the viral genome by viral RNA-dependent RNA polymerase (RdRp). Seasonal epidemics of influenza are also known to occur because of new variants of influenza A virus (IAV), which are generated by the introduction of mutations by viral RdRp with low fidelity. Variants with different antigenicities appear because of mutations in envelope glycoproteins. In this study, we calculated and compared the mutation rates in genome replication of IAV and SARS-CoV-2. Average mutation rates per passage were 9.01 × 10^-5 and 3.76 × 10^-6 substitutions/site for IAV and SARS-CoV-2, respectiv

SUBMITTER: Kawasaki Y 

PROVIDER: S-EPMC10421855 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature