Characterizing the circadian connectome of Ocimum tenuiflorum using an integrated network theoretic framework.

ABSTRACT: Across the three domains of life, circadian clock is known to regulate vital physiological processes, like, growth, development, defence etc. by anticipating environmental cues. In this work, we report an integrated network theoretic methodology comprising of random walk with restart and graphlet degree vectors to characterize genome wide core circadian clock and clock associated raw candidate proteins in a plant for which protein interaction information is available. As a case study, we have implemented this framework in Ocimum tenuiflorum (Tulsi); one of the most valuable medicinal plants that has been utilized since ancient times in the management of a large number of diseases. For that, 24 core clock (CC) proteins were mined in 56 template plant genomes to build their hidden Markov mod

SUBMITTER: Singh V 

PROVIDER: S-EPMC10421869 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature