A genome-wide by PM₁₀ exposure interaction study for blood pressure in Korean adults.

ABSTRACT: Blood pressure (BP) is a typical complex trait, and the genetic susceptibility of individuals to changes in BP induced by air pollution exposure is different. Although interactions of exposure to air pollutants with several candidate genes have been identified, genome-wide interaction studies (GWISs) are needed to understand the association between them with BP. Therefore, we aimed to discover the unique genetic loci for BP that interact with exposure to air pollutants in Korean adults. We ultimately included 1868 participants in the discovery step and classified them into groups of those with low-to-moderate exposure and high exposure to average annual concentration of particulate matter with an aerodynamic diameter ≤ 10 μm (PM₁₀). Because none of the single nucleotide polymorp

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC10421905 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature