Preclinical Serological Signatures are Associated With Complicated Crohn's Disease Phenotype at Diagnosis.

ABSTRACT:

Background

At diagnosis, up to one-third of patients with Crohn's disease (CD) have a complicated phenotype with stricturing (B2) or penetrating (B3) behavior or require early surgery. We evaluated protein biomarkers and antimicrobial antibodies in serum archived years before CD diagnosis to assess whether complicated diagnoses were associated with a specific serological signature.

Methods

Prediagnosis serum was obtained from 201 patients with CD and 201 healthy controls. Samples were evaluated with a comprehensive panel of 1129 proteomic markers (SomaLogic) and antimicrobial antibodies. CD diagnosis and complications were defined by the International Classification of Diseases-Ninth Revision and Current Procedural Terminology codes. Cox regression models were utilized to as

SUBMITTER: Choung RS 

PROVIDER: S-EPMC10421963 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature