Subtypes of human immunodeficiency virus type 1 and disease stage among women in Nairobi, Kenya.

ABSTRACT: In sub-Saharan Africa, where the effects of human immunodeficiency virus type 1 (HIV-1) have been most devastating, there are multiple subtypes of this virus. The distribution of different subtypes within African populations is generally not linked to particular risk behaviors. Thus, Africa is an ideal setting in which to examine the diversity and mixing of viruses from different subtypes on a population basis. In this setting, it is also possible to address whether infection with a particular subtype is associated with differences in disease stage. To address these questions, we analyzed the HIV-1 subtype, plasma viral loads, and CD4 lymphocyte levels in 320 women from Nairobi, Kenya. Subtype was determined by a combination of heteroduplex mobility assays and sequence analyses of envelope

SUBMITTER: Neilson JR 

PROVIDER: S-EPMC104220 | biostudies-literature | 1999 May

REPOSITORIES: biostudies-literature