Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration.

ABSTRACT:

Background

The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and fibre typing of skeletal muscle fibres, as seen during regeneration and in certain muscle diseases, can be challenging to interpret. Neuromuscular electrical stimulation can induce myofibre necrosis followed by changes in spatial and temporal cellular processes. Thirty days following electrical stimulation, remnants of regeneration can be seen in the myofibre and its basement membrane as the presence of small myofibres and encroachment of sarcolemma and basement membrane (suggestive of myofibre branching/splitting). The purpose of this study was to investigate myofibre branching and fibre type in a systematic manner in human skeletal muscle undergoin

SUBMITTER: Hojfeldt G 

PROVIDER: S-EPMC10422711 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature