The prevalence of bronchiectasis in patients with alpha-1 antitrypsin deficiency: initial report of EARCO.

ABSTRACT:

Background

Although bronchiectasis has been recognised as a feature of some patients with Alpha1-Antitrypsin deficiency the prevalence and characteristics are not widely known. We wished to determine the prevalence of bronchiectasis and patient characteristics. The first cohort of patients recruited to the EARCO (European Alpha1 Research Collaboration) International Registry data base by the end of 2021 was analysed for radiological evidence of both emphysema and bronchiectasis as well as baseline demographic features.

Results

Of the first 505 patients with the PiZZ genotype entered into the data base 418 (82.8%) had a reported CT scan. There were 77 (18.4%) with a normal scan and 38 (9.1%) with bronchiectasis alone. These 2 groups were predominantly female never smokers and

SUBMITTER: Stockley RA 

PROVIDER: S-EPMC10422747 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature