Radiation dose is associated with improved local control for large, but not small, hepatocellular carcinomas.

ABSTRACT:

Background

With advances in understanding liver tolerance, conformal techniques, image guidance, and motion management, dose-escalated radiotherapy has become a potential treatment for inoperable hepatocellular carcinoma (HCC). We aimed to evaluate the possible impact of biologically effective dose (BED) on local control and toxicity among patients with HCC.

Methods and materials

Patients treated at our institution from 2009 to 2018 were included in this retrospective analysis if they received definitive-intent radiotherapy with a nominal BED of at least 60 Gy. Patients were stratified into small and large tumors using a cutoff of 5 cm, based on our clinical practice. Toxicity was assessed using ALBI scores and rates of clinical liver function deterioration.

Results

O

SUBMITTER: Amit U 

PROVIDER: S-EPMC10422771 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature