Cortical regulation of neurogenesis and cell proliferation in the ventral subventricular zone.

ABSTRACT: Neurogenesis and differentiation of neural stem cells (NSCs) are controlled by cell-intrinsic molecular pathways that interact with extrinsic signaling cues. In this study, we identify a circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone (LV-SVZ). Our results demonstrate that direct glutamatergic projections from the anterior cingulate cortex (ACC), as well as inhibitory projections from calretinin⁺ local interneurons, modulate the activity of cholinergic neurons in the subependymal zone (subep-ChAT⁺). Furthermore, in vivo optogenetic stimulation and inhibition of the ACC-subep-ChAT⁺ circuit are sufficient to control neurogenesis in the ventral SVZ. Both subep-ChAT⁺ and local calretinin^+</

SUBMITTER: Naffaa MM 

PROVIDER: S-EPMC10422956 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature