Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy.

ABSTRACT: Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years, macrophages have become promising cellular carriers for drug and nanoparticle delivery to the tumor microenvironment, mainly due to their natural properties such as biocompatibility, degradability, lack of immunogenicity, long half-life in circulation, crossing biological barriers, and the possibility of migration and accumulation at a site of inflammation such as a tumor. For the effectiveness of this therapeutic strategy, known as "Trojan horse", it is important that the nanoparticles engulfed

SUBMITTER: Wroblewska A 

PROVIDER: S-EPMC10422973 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature