High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients.

ABSTRACT:

Introduction

Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the ubiquitin-specific protease (USP4) on survival was only scarcely investigated so far. The goal of our research was to analyze the association of USP4 expression with prognosis and clinicopathological features in HNSCC.

Methods

USP4 mRNA levels were derived from The Cancer Genome Atlas (TCGA) for a cohort of 510 patients. Protein expression of USP4 was analyzed by immunohistochemistry in a second cohort of 113 patients. Associations between USP4 levels and overall survival, disease-f

SUBMITTER: Scheiflinger A 

PROVIDER: S-EPMC10423105 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature