Polydatin radiosensitizes lung cancer while preventing radiation injuries by modulating tumor-infiltrating B cells.

ABSTRACT:

Background

Acquired radio-resistance and the undesired normal tissue radiation injuries seriously discount the therapeutic effect of lung cancer radiotherapy. In this study, we aimed to explore the role and potential mechanism of polydatin in simultaneously decreasing radioresistance and radiation injuries.

Methods

The tumor-bearing model of nude mice was used to investigate the tumor inhibition of polydatin on lung cancer and its effect on radiosensitivity, and the effect of polydatin on B cell infiltration in cancerous tissue was investigated. In addition, we performed systemic radiotherapy on BABL/C mice and evaluated the protective effect of polydatin on radiation injury by the Kaplan-Meier survival curve. Moreover, the regulation of polydatin on proliferation and apopto

SUBMITTER: Guo J 

PROVIDER: S-EPMC10423126 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature