Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk.

ABSTRACT:

Background

Individual colorectal polyp risk factors are well characterized; however, insights into their pathway-specific interactions are scarce. We aimed to identify the impact of individual risk factors and their joint effects on adenomatous (AP) and serrated polyp (SP) risk.

Methods

We collected information on 363 lifestyle and metabolic parameters from 1597 colonoscopy participants, resulting in over 521,000 data points. We used multivariate statistics and machine-learning approaches to assess associations of single variables and their interactions with AP and SP risk.

Results

Individual factors and their interactions showed common and polyp subtype-specific effects. Abdominal obesity, high body mass index (BMI), metabolic syndrome, and red meat consumption globa

SUBMITTER: Kim J 

PROVIDER: S-EPMC10423128 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature