LAG3 in gastric cancer: it's complicated.

ABSTRACT:

Purpose

Lymphocyte activation gene 3 (LAG3) is thought to contribute to T cell exhaustion within the tumor microenvironment of solid tumors. This study aimed to analyze the spatial distribution of LAG3 + cells in relation to clinicopathological and survival data in a large set of 580 primary resected and neoadjuvantly treated gastric cancers (GC).

Methods

LAG3 expression was evaluated in tumor center and invasive margin using immunohistochemistry and whole-slide digital image analysis. Cases were divided into LAG3-low and LAG3-high expression groups based on (1) median LAG3 + cell density, (2) cut-off values adapted to cancer-specific survival using Cutoff Finder application.

Results

Significant differences in spatial distribution of LAG3 + cells were observed in prim

SUBMITTER: Ulase D 

PROVIDER: S-EPMC10423140 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature