The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma.

ABSTRACT:

Purpose

Abnormalities in the mitotic spindle have been linked to a variety of cancers. Data on their role in the onset, progression, and treatment of lung adenocarcinoma (LUAD) need to be explored.

Methods

The data were retrieved from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Molecular Signatures Database (MSigDB), for the training cohort, external validation cohort, and the hallmark mitotic spindle gene set, respectively. Mitotic spindle genes linked to LUAD prognosis were identified and intersected with differentially expressed up-regulated genes in the training cohort. Nomogram prediction models were built based on least absolute shrinkage and selection operator (LASSO) regression, univariate cox, and multivariate cox analyses. The seven-gene immu

SUBMITTER: Shen R 

PROVIDER: S-EPMC10423164 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature