Differences of genomic alterations and heavy metals in non-small cell lung cancer with different histological subtypes.

ABSTRACT:

Purpose

This study aimed to explore the correlations among heavy metals concentration, histologic subtypes and molecular characteristics in patients with non-small cell lung cancer (NSCLC).

Methods

In this study, an NGS panel of 82 tumor-associated genes was used to identify genomic alternations in 180 newly diagnosed patients with NSCLC. The concentrations of 18 heavy metals in the serum samples were detected by inductively coupled plasma emission spectrometry (ICP-MS).

Results

A total of 243 somatic mutations of 25 mutant genes were identified in 115 of 148 patients with LUAD and 45 somatic mutations of 15 mutant genes were found in 24 of 32 patients with LUSC. The genomic alternations, somatic interactions, traditional serum biomarkers, and heavy metals were marked

SUBMITTER: Mu D 

PROVIDER: S-EPMC10423170 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature