In vitro antibiofilm and bacteriostatic activity of diacerein against Enterococcus faecalis.

ABSTRACT: Enterococcus faecalis is one of the main pathogens that causes hospital-acquired infections because it is intrinsically resistant to some antibiotics and often is capable of biofilm formation, which plays a critical role in resisting the external environment. Therefore, attacking biofilms is a potential therapeutic strategy for infections caused by E. faecalis. Current research indicates that diacerein used in the treatment of osteoarthritis showed antimicrobial activity on strains of gram-positive cocci in vitro. In this study, we tested the MICs of diacerein using the broth microdilution method, and successive susceptibility testing verified that E. faecalis is unlikely to develop resistance to diacerein. In addition, we obtained a strain of E. faecalis HE01 with strong biofilm-forming a

SUBMITTER: Fu C 

PROVIDER: S-EPMC10423188 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature