^99mTc-macroaggregated albumin SPECT/CT predictive dosimetry and dose-response relationship in uveal melanoma liver metastases treated with first-line selective internal radiation therapy.

ABSTRACT: First-line selective internal radiation therapy (SIRT) showed promising outcomes in patients with uveal melanoma liver metastases (UMLM). Patient survival depends on liver's disease control. SIRT planning is essential and little is known about dosimetry. We investigated whether ^99mTc-MAA-SPECT/CT dosimetry could predict absorbed doses (AD) evaluated on ⁹⁰Y-PET/CT and assess the dose-response relationship in UMLM patients treated with first-line SIRT. This IRB-approved, single-center, retrospective analysis (prospectively collected cohort) included 12 patients (median age 63y, range 43-82). Patients underwent MRI/CT, ¹⁸F-FDG-PET/CT before and 3-6 months post-SIRT, and ⁹⁰Y-PET/CT immediately post-SIRT. Thirty-two target lesions were included. AD es

SUBMITTER: Tabotta F 

PROVIDER: S-EPMC10423257 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature