Improved [⁶⁸Ga]Ga-PSMA-11 image qualities reconstructed by total variation regularized expectation maximization on total-body PET/CT.

ABSTRACT:

Background

Total variation regularized expectation maximization (TVREM) reconstruction algorithm on the image quality of gallium (⁶⁸GA) prostate-specific membrane antigen-11 ([⁶⁸Ga]Ga-PSMA-11) total-body positron emission tomography/computed tomography (PET/CT).

Methods

Images of a phantom with small hot sphere inserts and the total-body PET/CT scans of 51 prostate cancer patients undergoing [⁶⁸Ga]Ga-PSMA-11 were reconstructed using TVREM with 5 different penalization factors between 0.09 and 0.45 and for 20-, 40-, 60-, 120-, and 300-second acquisition, respectively. As a comparison, the same data were also reconstructed using the ordered subset expectation maximization (OSEM) with 3 iterations, 20 subsets, and 300 second acquisition. The con

SUBMITTER: Li L 

PROVIDER: S-EPMC10423362 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature