Biodistribution and radiation dosimetry of multiple tracers on total-body positron emission tomography/computed tomography.

ABSTRACT:

Background

[¹⁸F]F-FDG, [⁶⁸Ga]Ga-PSMA-11, and [⁶⁸Ga]Ga-FAPI-04 have achieved good results in multiple clinical trials and clinical practice, but the imaging of these tracers is limited to traditional short-axis positron emission tomography/computed tomography (PET/CT). Therefore, we aimed to use total-body PET/CT dynamic scanning to describe whole-body biodistribution of these three tracers and to calculate more precise radiation doses.

Methods

Total-body PET/CT (uExplorer, United Imaging Healthcare) dynamic scanning was performed on 54 patients, including 30 patients with [¹⁸F]F-FDG, 10 patients with [⁶⁸Ga]Ga-PSMA-11, and 14 patients with [⁶⁸Ga]Ga-FAPI-04. A 60-minute dynamic scanning of whole body was perform

SUBMITTER: Li L 

PROVIDER: S-EPMC10423372 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature