Feasibility evaluation of middle-phase ¹⁸F-florbetaben positron emission tomography imaging using centiloid quantification and visual assessment.

ABSTRACT:

Background

¹⁸F-florbetaben (FBB) positron emission tomography (PET) scan has been widely used in research and routine clinical practice. Most studies used late-phase (scanning from 90 to 110 min after injection) FBB scans to generate beta-amyloid accumulation data. The feasibility of middle-phase scan is seldom discussed. Using the middle-phase data can shorten the patients' waiting between the injection and scan, and hospital can acquire more flexible schedule of routine scan.

Methods

Paired middle-phase (60-80 min) FBB scans and standard (90-110 min) FBB scans were obtained from 27 subjects (12 neurodegenerative dementia, 8 mild cognitive impairment, 3 normal control, and 4 patients not suffering from neurodegenerative dementia). Standardized uptake value ratios

SUBMITTER: Wu CH 

PROVIDER: S-EPMC10423384 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature