Quantitative analysis of contrast-enhanced ultrasonography in rat models of hepatic acute graft-versus-host disease.

ABSTRACT:

Background

Hepatic acute graft-versus-host disease (aGVHD) is a major life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We hypothesized that contrast-enhanced ultrasound (CEUS) could serve as a new imaging biomarker in early diagnosis of hepatic aGVHD by detecting liver microcirculation.

Methods

Thirty Wistar rats received allo-HSCT were finally included after excluding 9 rats, and they were randomly divided into 5 groups (1- to 5-week groups, 6 per group). Six rats were used for the control group without any intervention. We observed the clinical scores, serum liver enzyme levels and liver CEUS parameters of rats in each group. Hepatic aGVHD was finally confirmed by histopathologic analysis. The diagnostic performance of CEUS p

SUBMITTER: Xin Y 

PROVIDER: S-EPMC10423398 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature