Serum lipidome unravels a diagnostic potential in bile acid diarrhoea.

ABSTRACT:

Objective

Bile acid diarrhoea (BAD) is debilitating yet treatable, but it remains underdiagnosed due to challenging diagnostics. We developed a blood test-based method to guide BAD diagnosis.

Design

We included serum from 50 treatment-naive patients with BAD diagnosed by gold standard ⁷⁵selenium homotaurocholic acid test, 56 feature-matched controls and 37 patients with non-alcoholic fatty liver disease (NAFLD). Metabolomes were generated using mass spectrometry covering 1295 metabolites and compared between groups. Machine learning was used to develop a BAD Diagnostic Score (BDS).

Results

Metabolomes of patients with BAD significantly differed from controls and NAFLD. We detected 70 metabolites with a discriminatory performance in the discovery set with an

SUBMITTER: Lewinska M 

PROVIDER: S-EPMC10423493 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature