Dataset Information

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers.

ABSTRACT:

Background

Betel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties. We investigated the association between statin use and ESCC risk in betel nut chewers.

Methods

The study included 105 387 betel nut chewers matched statin users and nonusers. Statin use was defined as the use of ≥28 cumulative defined daily doses (cDDDs) of statin. The primary outcome was incidence of ESCC.

Results

The incidence rate of ESCC was significantly lower in statin users than in nonusers (2.03 vs. 3.02 per 100 000 person-years). Statin users had a lower incidence rate ratio of 0.66 for ESCC (95% confidence interval [CI]: 0.43-0.85) relative to nonusers. After potential confounders were adjusted for, statin use was determined to be associated with a reduced risk of ESCC (adjusted hazard ratio [aHR], 0.68; 95% CI: 0.51-0.91). A dose-response relationship was observed between statin use and ESCC risk; the aHRs for statin use at 28-182 cDDDs, 183-488 cDDDs, 489-1043 cDDDs, and > 1043 cDDDs were 0.92, 0.89, 0.66, and 0.64, respectively.

Conclusion

Statin use was revealed to be associated with a reduced risk of ESCC in betel nut chewers.

SUBMITTER: Lin CL

PROVIDER: S-EPMC10423659 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers.

Lin Chih-Lang CL Chen Wan-Ming WM Shia Ben-Chang BC Wu Szu-Yuan SY

Thoracic cancer 20230703 23

<h4>Background</h4>Betel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties. We investigated the association between statin use and ESCC risk in betel nut chewers.<h4>Methods</h4>The study included 105 387 betel nut chewers matched statin users and nonusers. Statin use was defined as the use of ≥28 cumulative defined daily dos ...[more]

PMID: 37395565

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Dataset Information

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers.

Background

Methods

Results

Conclusion

Publications

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers.

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