Segmented filamentous bacteria-based treatment to elicit protection against Enterobacteriaceae in Layer chickens.

ABSTRACT:

Introduction

Gut microbes like segmented filamentous bacteria (SFB) play a key role in gut maturation during early life, as demonstrated in humans and mice. Our previous study demonstrated oral inoculation of ileum-spores containing SFB to chickens after hatch increases early SFB gut colonization, which increases immune maturation and resistance to bacteria, like Salmonella, as tested in vitro; however, more studies are needed for treatment optimization and in vivo testing. The objectives of this study were to (1) test a treatment that includes both spores and filamentous SFB, (2) validate antimicrobial ability of the treatment in layer hens in vivo, and (3) elucidate its molecular mechanism.

Methods

One-day-old specific pathogen-free layers (n

SUBMITTER: Meinen-Jochum J 

PROVIDER: S-EPMC10423809 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature